What the FDA labels say about taking them together
Estrogens conjugated and itraconazole
Estrogens conjugated's FDA label of June 4, 2026 names itraconazole in its drug interactions section; the itraconazole labels PlainMeds reads (2) do not name estrogens conjugated. The estrogens conjugated label: “Inhibitors of CYP3A4, such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice, may increase plasma concentrations of estrogens and may result in side effects.”
Check it at the source: the estrogens conjugated FDA label on DailyMed (effective June 4, 2026, Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the estrogens conjugated label say about itraconazole?
Estrogens conjugated label, drug interactionsInhibitors of CYP3A4, such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice, may increase plasma concentrations of estrogens and may result in side effects.
Source: FDA drug label (Premarin), Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., effective June 4, 2026 (SPL set 258e1602-a3cf-4ccc-ca80-73dbbfb812ff), via openFDA; the full label on DailyMed
What does the itraconazole label say about estrogens conjugated?
Itraconazole's label (effective July 13, 2026) and its 1 other brand-application label do not name estrogens conjugated in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Estrogens conjugated | Itraconazole | |
|---|---|---|
| Labeled for | Menopause symptoms, Breast cancer, Osteoporosis | Fungal infections |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $5.47 per tablet 0.625 mg tablet | $0.910 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once