What the FDA labels say about taking them together
Colestipol and pravastatin
Pravastatin's FDA label of July 31, 2026 names colestipol in its drug interactions section; the colestipol labels PlainMeds reads (3) do not name pravastatin. The pravastatin label: “Concomitant cholestyramine or colestipol administration decreased the mean exposure of pravastatin approximately 51% and 47%, respectively.”
Check it at the source: the colestipol FDA label on DailyMed (effective February 19, 2024, Zydus Pharmaceuticals USA Inc.); the pravastatin FDA label on DailyMed (effective July 31, 2026, Apotex Corp.).
What does the colestipol label say about pravastatin?
Colestipol's label (effective February 19, 2024) and its 2 other brand-application labels do not name pravastatin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Colestipol hydrochloride), Zydus Pharmaceuticals USA Inc., effective February 19, 2024 (SPL set 71f12e0d-373a-4867-b37c-f24d99c5ce95), via openFDA; the full label on DailyMed
What does the pravastatin label say about colestipol?
Pravastatin label, drug interactionsBile Acid Sequestrants Clinical Impact: Concomitant cholestyramine or colestipol administration decreased the mean exposure of pravastatin approximately 51% and 47%, respectively. Intervention: In patients taking a bile acid sequestrant, administer pravastatin at least 1 hour before or at least 4 hours after the bile acid sequestrant [see Dosage and Administration ()].
Source: FDA drug label (PRAVASTATIN SODIUM), Apotex Corp., effective July 31, 2026 (SPL set dcf45e4f-b46e-6fbb-b67a-2ff619ab1780), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colestipol | Pravastatin | |
|---|---|---|
| Labeled for | High cholesterol | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.658 per tablet 1 g tablet | $0.058 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once