What the FDA labels say about taking them together
Colesevelam and odevixibat
Odevixibat's FDA label of December 29, 2025 names colesevelam in its drug interactions section; the colesevelam label PlainMeds reads does not name odevixibat. The odevixibat label: “DRUG INTERACTIONS 7.1 Bile Acid Binding Resins Administer bile acid binding resins at least 4 hours before or 4 hours after administration of BYLVAY.”
Check it at the source: the colesevelam FDA label on DailyMed (effective December 28, 2023, A-S Medication Solutions); the odevixibat FDA label on DailyMed (effective December 29, 2025, Ipsen Biopharmaceuticals, Inc.).
What does the colesevelam label say about odevixibat?
Colesevelam's label (effective December 28, 2023) does not name odevixibat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (COLESEVELAM HYDROCHLORIDE), NDA021176 (Cosette), as published by A-S Medication Solutions, effective December 28, 2023 (SPL set 0127afae-8d8d-43f2-97f9-4f99f6947e81), via openFDA; the full label on DailyMed
What does the odevixibat label say about colesevelam?
Odevixibat label, drug interactionsDRUG INTERACTIONS 7.1 Bile Acid Binding Resins Administer bile acid binding resins (e.g., cholestyramine, colesevelam, or colestipol) at least 4 hours before or 4 hours after administration of BYLVAY [see Dosage and Administration (2.3) ].
Source: FDA drug label (Bylvay), Ipsen Biopharmaceuticals, Inc., effective December 29, 2025 (SPL set 0935cd31-3251-4a0a-ac23-25ca4be12be9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colesevelam | Odevixibat | |
|---|---|---|
| Labeled for | High cholesterol, Type 2 diabetes | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.262 per tablet 625 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once