What the FDA labels say about taking them together
Colesevelam and maralixibat
Maralixibat's FDA label of April 10, 2025 names colesevelam in its drug interactions section; the colesevelam label PlainMeds reads does not name maralixibat.
Check it at the source: the colesevelam FDA label on DailyMed (effective December 28, 2023, A-S Medication Solutions); the maralixibat FDA label on DailyMed (effective April 10, 2025, Mirum Pharmaceuticals Inc.).
What does the colesevelam label say about maralixibat?
Colesevelam's label (effective December 28, 2023) does not name maralixibat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (COLESEVELAM HYDROCHLORIDE), NDA021176 (Cosette), as published by A-S Medication Solutions, effective December 28, 2023 (SPL set 0127afae-8d8d-43f2-97f9-4f99f6947e81), via openFDA; the full label on DailyMed
What does the maralixibat label say about colesevelam?
Maralixibat label, drug interactionsAdminister LIVMARLI at least 4 hours before or 4 hours after administration of bile acid binding resins (e.g., cholestyramine, colesevelam, or colestipol).
Source: FDA drug label (Livmarli), Mirum Pharmaceuticals Inc., effective April 10, 2025 (SPL set 64000394-1ef6-4e76-8ba8-11f25ba1b167), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colesevelam | Maralixibat | |
|---|---|---|
| Labeled for | High cholesterol, Type 2 diabetes | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.262 per tablet 625 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once