What the FDA labels say about taking them together
Colesevelam and ethinyl estradiol/norelgestromin
Ethinyl estradiol/norelgestromin's FDA label (Gwyn Lo) of July 6, 2026 names colesevelam in its drug interactions section; the colesevelam label PlainMeds reads does not name ethinyl estradiol/norelgestromin. The ethinyl estradiol/norelgestromin label: “Concomitant use of CHCs with colesevelam significantly decreases systemic exposure of ethinyl estradiol.”
Check it at the source: the colesevelam FDA label on DailyMed (effective December 28, 2023, A-S Medication Solutions); the ethinyl estradiol/norelgestromin FDA label on DailyMed (effective April 16, 2026, Zydus Pharmaceuticals USA Inc.).
What does the colesevelam label say about ethinyl estradiol/norelgestromin?
Colesevelam's label (effective December 28, 2023) does not name ethinyl estradiol/norelgestromin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (COLESEVELAM HYDROCHLORIDE), NDA021176 (Cosette), as published by A-S Medication Solutions, effective December 28, 2023 (SPL set 0127afae-8d8d-43f2-97f9-4f99f6947e81), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/norelgestromin label say about colesevelam?
Gwyn Lo label (Viatris Specialty LLC, July 6, 2026), drug interactionsConcomitant use of CHCs with colesevelam significantly decreases systemic exposure of ethinyl estradiol.
Source: FDA drug label (Gwyn Lo, NDA219990), Viatris Specialty LLC, effective July 6, 2026 (SPL set e92741f4-87fe-429f-b5b5-c558ed5f4fa9), via openFDA
Source: FDA drug label (norelgestromin and ethinyl estradiol), Zydus Pharmaceuticals USA Inc., effective April 16, 2026 (SPL set 10fa1458-c8ed-4197-922a-1ba7271d2b02), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colesevelam | Ethinyl estradiol/norelgestromin | |
|---|---|---|
| Labeled for | High cholesterol, Type 2 diabetes | Birth control |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.262 per tablet 625 mg tablet | $37.16 per patch 150-35 mcg/day patch |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once