What the FDA labels say about taking them together
Colchicine and ranolazine
Colchicine's FDA label (Lodoco) of August 13, 2026 names ranolazine in its drug interactions section; the ranolazine labels PlainMeds reads (2) do not name colchicine. The colchicine label: “Significant increase in colchicine plasma levels is anticipated with P-gp inhibitors.”
Check it at the source: the colchicine FDA label on DailyMed (effective July 22, 2025, Aurobindo Pharma Limited); the ranolazine FDA label on DailyMed (effective January 23, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the colchicine label say about ranolazine?
Lodoco label (AGEPHA Pharma USA, LLC, August 13, 2026), drug interactionsDrug class: P- glycoprotein Inhibitors † cyclosporine ranolazine; Outcome/effect: Significant increase in colchicine plasma levels is anticipated with P-gp inhibitors.; Clinical comment: Concomitant use of LODOCO with strong P-gp inhibitors is contraindicated [see Contraindications (4)].
Source: FDA drug label (Lodoco, NDA215727), AGEPHA Pharma USA, LLC, effective August 13, 2026 (SPL set ff06d68f-d65f-d097-e053-6294a90a7e5f), via openFDA
Source: FDA drug label (Colchicine), Aurobindo Pharma Limited, effective July 22, 2025 (SPL set dd93a40f-92ab-47ac-9083-b8a7a0b18ad6), via openFDA; the full label on DailyMed
What does the ranolazine label say about colchicine?
Ranolazine's label (effective January 23, 2026) and its 1 other brand-application label do not name colchicine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ranolazine), Glenmark Pharmaceuticals Inc., USA, effective January 23, 2026 (SPL set 0cf58732-c242-49b0-8e3f-248778b4458d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colchicine | Ranolazine | |
|---|---|---|
| Labeled for | Gout | Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.122 per tablet 0.6 mg tablet | $0.165 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once