What the FDA labels say about taking them together
Colchicine and pegloticase
Pegloticase's FDA label of July 9, 2026 names colchicine in its warnings and precautions section; the colchicine labels PlainMeds reads (4) do not name pegloticase. The pegloticase label: “Gout flare prophylaxis with a non-steroidal anti-inflammatory drug (NSAID) or colchicine is recommended starting at least 1 week before initiation of KRYSTEXXA therapy and lasting at least 6 months, unless medically …”
Check it at the source: the colchicine FDA label on DailyMed (effective July 22, 2025, Aurobindo Pharma Limited); the pegloticase FDA label on DailyMed (effective July 9, 2026, Horizon Therapeutics USA, Inc.).
What does the colchicine label say about pegloticase?
Colchicine's label (effective July 22, 2025) and its 3 other brand-application labels do not name pegloticase in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Colchicine), Aurobindo Pharma Limited, effective July 22, 2025 (SPL set dd93a40f-92ab-47ac-9083-b8a7a0b18ad6), via openFDA; the full label on DailyMed
What does the pegloticase label say about colchicine?
Pegloticase label, warnings and precautionsGout flare prophylaxis with a non-steroidal anti-inflammatory drug (NSAID) or colchicine is recommended starting at least 1 week before initiation of KRYSTEXXA therapy and lasting at least 6 months, unless medically contraindicated or not tolerated.
Source: FDA drug label (Krystexxa), Horizon Therapeutics USA, Inc., effective July 9, 2026 (SPL set 6e566303-d93a-4130-b764-25749829aa95), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colchicine | Pegloticase | |
|---|---|---|
| Labeled for | Gout | Gout |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.122 per tablet 0.6 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once