What the FDA labels say about taking them together
Colchicine and nefazodone
Colchicine's FDA label (Lodoco) of August 13, 2026 names nefazodone in its drug interactions section; the nefazodone label PlainMeds reads does not name colchicine. The colchicine label: “Significant increases in colchicine plasma levels.”
Check it at the source: the colchicine FDA label on DailyMed (effective July 22, 2025, Aurobindo Pharma Limited); the nefazodone FDA label on DailyMed (effective July 31, 2025, Teva Pharmaceuticals USA, Inc.).
What does the colchicine label say about nefazodone?
Lodoco label (AGEPHA Pharma USA, LLC, August 13, 2026), drug interactionsDrug class: Strong CYP3A4 Inhibitors † atazanavir clarithromycin darunavir/ritonavir indinavir itraconazole ketoconazole lopinavir/ritonavir nefazodone nelfinavir ritonavir saquinavir telithromycin tipranavir/ritonavir; Outcome/effect: Significant increases in colchicine plasma levels [see Clinical Pharmacology (12.3)].; Clinical comment: Concomitant use of LODOCO with strong CYP3A4 inhibitors is contraindicated [see Contraindications (4)].
Source: FDA drug label (Lodoco, NDA215727), AGEPHA Pharma USA, LLC, effective August 13, 2026 (SPL set ff06d68f-d65f-d097-e053-6294a90a7e5f), via openFDA
Source: FDA drug label (Colchicine), Aurobindo Pharma Limited, effective July 22, 2025 (SPL set dd93a40f-92ab-47ac-9083-b8a7a0b18ad6), via openFDA; the full label on DailyMed
What does the nefazodone label say about colchicine?
Nefazodone's label (effective July 31, 2025) does not name colchicine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nefazodone Hydrochloride), Teva Pharmaceuticals USA, Inc., effective July 31, 2025 (SPL set 51ff7db5-aaf9-4c3c-86e6-958ebf16b60f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colchicine | Nefazodone | |
|---|---|---|
| Labeled for | Gout | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.122 per tablet 0.6 mg tablet | $1.17 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once