What the FDA labels say about taking them together
Colchicine and ensitrelvir
Ensitrelvir's FDA label of June 3, 2026 names colchicine in its drug interactions section; the colchicine labels PlainMeds reads (4) do not name ensitrelvir. The ensitrelvir label: “Co-administration is contraindicated due to potential for serious and/or life-threatening reactions in patients with renal and/or hepatic impairment.”
Check it at the source: the colchicine FDA label on DailyMed (effective July 22, 2025, Aurobindo Pharma Limited); the ensitrelvir FDA label on DailyMed (effective June 3, 2026, Shionogi Inc.).
What does the colchicine label say about ensitrelvir?
Colchicine's label (effective July 22, 2025) and its 3 other brand-application labels do not name ensitrelvir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Colchicine), Aurobindo Pharma Limited, effective July 22, 2025 (SPL set dd93a40f-92ab-47ac-9083-b8a7a0b18ad6), via openFDA; the full label on DailyMed
What does the ensitrelvir label say about colchicine?
Ensitrelvir label, drug interactionsDrug Class: Antigout agents; Drug (s) within Class: colchicine; Effect on Drug Concentration: ↑ colchicine; Clinical Comment: Co-administration is contraindicated due to potential for serious and/or life-threatening reactions in patients with renal and/or hepatic impairment.
Source: FDA drug label (XOCOVA), Shionogi Inc., effective June 3, 2026 (SPL set 526acf60-abc3-2cc2-e063-6294a90affa6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colchicine | Ensitrelvir | |
|---|---|---|
| Labeled for | Gout | COVID-19 |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.122 per tablet 0.6 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once