Cyclosporine · more major-labeled pairs than Colchicine
SPL labels Colchicine + Cyclosporine as minor; Colchicine 15 / Cyclosporine 60 in that band.
Mechanism on file: Cyclosporine prevents your body from getting rid of colchicine, causing it to build up to dangerous levels. This combination increases the risk of serious muscle breakdown.
FDA SPL severity: Minor
Colchicine + Cyclosporine · SPL mechanism field
Cyclosporine prevents your body from getting rid of colchicine, causing it to build up to dangerous levels. This combination increases the risk of serious muscle breakdown.
Minor band excerpt · Colchicine with Cyclosporine
Other Lipid-Lowering Drugs: fibrates, gemfibrozil Digitalis Glycosides: digoxin P-gp substrate; rhabdomyolysis has been reported Coadministration of P-gp and/or CYP3A4 inhibitors (e.g., clarithromycin or cyclosporine) have been demonstrated to alter the concentration of colchicine. Drug Interactions: Pharmacokinetic Parameters for Colchicine Tablets in the Presence of the Coadministered Drug Coadministered Drug Dose of Coadministered Drug (mg) Dose of Colchicine Tablets (mg) N % Change in Colchicine Concentrations from Baseline (Range: Min – Max) C max AUC 0-t Cyclosporine 100 mg single...
Colchicine · 15 minor + 28 total pairs
- Azithromycin minor
- Digoxin minor
- Diltiazem minor
- Estradiol minor
Cyclosporine · 5 major-labeled pairs (vs Colchicine's 4)
- Adalimumab minor
- Amiodarone minor
- Amlodipine minor
- Anidulafungin minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.