What the FDA labels say about taking them together
Codeine/phenylephrine/promethazine and phentolamine
Codeine/phenylephrine/promethazine's FDA label of January 8, 2026 names phentolamine in its drug interactions section; the phentolamine labels PlainMeds reads (2) do not name codeine/phenylephrine/promethazine.
Check it at the source: the codeine/phenylephrine/promethazine FDA label on DailyMed (effective January 8, 2026, Amneal Pharmaceuticals LLC); the phentolamine FDA label on DailyMed (effective March 15, 2026, Oyster Point Pharma, Inc.).
What does the codeine/phenylephrine/promethazine label say about phentolamine?
Codeine/phenylephrine/promethazine label, drug interactionsDue to the antagonistic pharmacologic effects of phenylephrine, one of the active ingredients in Promethazine and Phenylephrine HCl and Codeine Phosphate Oral Solution, the concomitant use of Promethazine and Phenylephrine HCl and Codeine Phosphate Oral Solution with antihypertensive drugs, including alpha-adrenergic antagonists (e.g., phentolamine); mixed alpha- and beta-adrenoreceptor antagonists; calcium channel blockers (e.g., nifedipine);
Source: FDA drug label (Promethazine and Phenylephrine HCl, and Codeine Phosphate), Amneal Pharmaceuticals LLC, effective January 8, 2026 (SPL set 5f23b254-872b-4e88-91be-710c3ea7687b), via openFDA; the full label on DailyMed
What does the phentolamine label say about codeine/phenylephrine/promethazine?
Phentolamine's label (effective March 15, 2026) and its 1 other brand-application label do not name codeine/phenylephrine/promethazine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ryzumvi), NDA217064 (Famygen Life Sci), as published by Oyster Point Pharma, Inc., effective March 15, 2026 (SPL set 96bb1e53-c2cc-4e60-a21a-db0269c371bf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Codeine/phenylephrine/promethazine | Phentolamine | |
|---|---|---|
| Labeled for | Cough and cold | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once