What the FDA labels say about taking them together
Codeine/phenylephrine/promethazine and epinephrine
Codeine/phenylephrine/promethazine's FDA label of January 8, 2026 names epinephrine in its drug interactions section; epinephrine's label does not name codeine/phenylephrine/promethazine itself but warns about its class (Opioids (opioid agonists), phenothiazines).
Check it at the source: the codeine/phenylephrine/promethazine FDA label on DailyMed (effective January 8, 2026, Amneal Pharmaceuticals LLC); the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions).
What does the codeine/phenylephrine/promethazine label say about epinephrine?
Codeine/phenylephrine/promethazine label, drug interactionsDue to synergistic adrenergic effects of phenylephrine, one of the active ingredients in Promethazine and Phenylephrine HCl and Codeine Phosphate Oral Solution, the concomitant use of Promethazine and Phenylephrine HCl and Codeine Phosphate Oral Solution with sympathomimetic amines such as epinephrine, amphetamine, phenylpropanolamine, and bronchodilator beta 2 -adrenoreceptor agonists may result in tachycardia, arrhythmias, serious hypertensive response and possible stroke.
Source: FDA drug label (Promethazine and Phenylephrine HCl, and Codeine Phosphate), Amneal Pharmaceuticals LLC, effective January 8, 2026 (SPL set 5f23b254-872b-4e88-91be-710c3ea7687b), via openFDA; the full label on DailyMed
What does the epinephrine label say about codeine/phenylephrine/promethazine?
Epinephrine's label does not name codeine/phenylephrine/promethazine itself; it warns about its class (Opioids (opioid agonists), phenothiazines):
Epinephrine label, drug interactionsDrugs Antagonizing Pressor Effects of Epinephrine α-blockers, such as phentolamine Vasodilators, such as nitrates Diuretics Antihypertensives Ergot alkaloids Phenothiazine antipsychotics 7.2.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Codeine/phenylephrine/promethazine | Epinephrine | |
|---|---|---|
| Labeled for | Cough and cold | Asthma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $123.51 per unit 0.15 mg auto-injct |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once