What the FDA labels say about taking them together
Cocaine and thiotepa
Cocaine's FDA label of January 12, 2026 names thiotepa in its drug interactions section; the thiotepa label PlainMeds reads does not name cocaine. The cocaine label: “… glucocorticoids, antimyasthenics (neostigmine), cyclophosphamide, and possibly thiotepa.”
Check it at the source: the cocaine FDA label on DailyMed (effective January 12, 2026, OMNIVIUM PHARMACEUTICALS LLC.); the thiotepa FDA label on DailyMed (effective January 30, 2026, Amneal Pharmaceuticals LLC).
What does the cocaine label say about thiotepa?
Cocaine label, drug interactionsPlasma cholinesterase activity may be decreased by chronic administration of certain monoamine oxidase inhibitors, oral contraceptives, glucocorticoids, antimyasthenics (neostigmine), cyclophosphamide, and possibly thiotepa.
Source: FDA drug label (NUMBRINO), OMNIVIUM PHARMACEUTICALS LLC., effective January 12, 2026 (SPL set d724b5b4-6654-4bf5-9eed-e2c7943084ed), via openFDA; the full label on DailyMed
What does the thiotepa label say about cocaine?
Thiotepa's label (effective January 30, 2026) does not name cocaine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TEPADINA), NDA208264 (Adienne Sa), as published by Amneal Pharmaceuticals LLC, effective January 30, 2026 (SPL set 559e353c-2dc0-16ba-e054-00144ff8d46c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cocaine | Thiotepa | |
|---|---|---|
| Labeled for | n/a | Organ transplant rejection |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once