What the FDA labels say about taking them together
Cocaine and isocarboxazid
Isocarboxazid's FDA label of April 21, 2026 names cocaine in its contraindications section; cocaine's label does not name isocarboxazid itself but warns about its class (MAO inhibitors).
Check it at the source: the cocaine FDA label on DailyMed (effective January 12, 2026, OMNIVIUM PHARMACEUTICALS LLC.); the isocarboxazid FDA label on DailyMed (effective April 21, 2026, Lifsa Drugs LLC).
What does the cocaine label say about isocarboxazid?
Cocaine's label does not name isocarboxazid itself; it warns about its class (MAO inhibitors):
Cocaine label, drug interactionsPlasma cholinesterase activity may be decreased by chronic administration of certain monoamine oxidase inhibitors, oral contraceptives, glucocorticoids, antimyasthenics (neostigmine), cyclophosphamide, and possibly thiotepa.
Cocaine label, drug interactionsCocaine hydrochloride may potentiate the effects and toxicity of MAO inhibitors.
Source: FDA drug label (NUMBRINO), OMNIVIUM PHARMACEUTICALS LLC., effective January 12, 2026 (SPL set d724b5b4-6654-4bf5-9eed-e2c7943084ed), via openFDA; the full label on DailyMed
What does the isocarboxazid label say about cocaine?
Isocarboxazid label, contraindicationsAlso, they should not be given cocaine or local anesthesia containing sympathomimetic vasoconstrictors.
Source: FDA drug label (MARPLAN), Lifsa Drugs LLC, effective April 21, 2026 (SPL set 95fde749-44ad-4668-86c4-0ff17bca0074), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cocaine | Isocarboxazid | |
|---|---|---|
| Labeled for | n/a | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once