What the FDA labels say about taking them together

Cocaine and iobenguane i 123

Iobenguane i 123's FDA label of January 10, 2024 names cocaine in its drug interactions section; the cocaine labels PlainMeds reads (2) do not name iobenguane i 123. The iobenguane i 123 label: “… inhibit norepinephrine transporter function, sympathomimetic amines, and cocaine.”

Check it at the source: the cocaine FDA label on DailyMed (effective January 12, 2026, OMNIVIUM PHARMACEUTICALS LLC.); the iobenguane i 123 FDA label on DailyMed (effective January 10, 2024).

What does the cocaine label say about iobenguane i 123?

Cocaine's label (effective January 12, 2026) and its 1 other brand-application label do not name iobenguane i 123 in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (NUMBRINO), OMNIVIUM PHARMACEUTICALS LLC., effective January 12, 2026 (SPL set d724b5b4-6654-4bf5-9eed-e2c7943084ed), via openFDA; the full label on DailyMed

What does the iobenguane i 123 label say about cocaine?

Iobenguane i 123 label, drug interactions
DRUG INTERACTIONS The following drugs have the potential to decrease the uptake of norepinephrine and cause false negative imaging results: antihypertensives that deplete norepinephrine stores or inhibit reuptake (e.g., reserpine, labetalol), antidepressants that inhibit norepinephrine transporter function (e.g., amitriptyline and derivatives, imipramine and derivatives, selective serotonin reuptake inhibitors), sympathomimetic amines (e.g., phenylephrine, phenylpropanolamine, pseudoephedrine and ephedrine), and cocaine.

Source: FDA drug label (AdreView), Medi-Physics Inc., effective January 10, 2024 (SPL set c89d3ecc-4f4c-4566-8808-79152344194d), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Cocaine generic labelers

0Iobenguane i 123 generic labelers

	Cocaine	Iobenguane i 123
Labeled for	n/a	n/a
Boxed warning	Yes	No
Pharmacy cost (NADAC)	n/a	n/a
Shortage now	No current entry	No current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?

Cocaine: the full record
Iobenguane i 123: the full record
Check more medicines together: up to five at once