What the FDA labels say about taking them together
Cocaine and epinephrine
Cocaine's FDA label of January 12, 2026 names epinephrine in its drug interactions section; the epinephrine labels PlainMeds reads (4) do not name cocaine. The cocaine label: “Avoid use of additional vasoconstrictor agents such as epinephrine or phenylephrine with NUMBRINO.”
Check it at the source: the cocaine FDA label on DailyMed (effective January 12, 2026, OMNIVIUM PHARMACEUTICALS LLC.); the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions).
What does the cocaine label say about epinephrine?
Cocaine label, drug interactionsAvoid use of additional vasoconstrictor agents such as epinephrine and phenylephrine with NUMBRINO during nasal and sinus surgery.
Source: FDA drug label (Goprelto, NDA209963), LXO US Inc., effective November 6, 2024 (SPL set 0f897764-fe30-090a-e063-6294a90af106), via openFDA
Source: FDA drug label (NUMBRINO), OMNIVIUM PHARMACEUTICALS LLC., effective January 12, 2026 (SPL set d724b5b4-6654-4bf5-9eed-e2c7943084ed), via openFDA; the full label on DailyMed
What does the epinephrine label say about cocaine?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name cocaine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cocaine | Epinephrine | |
|---|---|---|
| Labeled for | n/a | Asthma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $123.51 per unit 0.15 mg auto-injct |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once