What the FDA labels say about taking them together
Cobimetinib and vemurafenib
Cobimetinib's FDA label of July 29, 2026 names vemurafenib in its warnings and precautions section; the vemurafenib label PlainMeds reads does not name cobimetinib.
Check it at the source: the cobimetinib FDA label on DailyMed (effective July 29, 2026, Genentech, Inc.); the vemurafenib FDA label on DailyMed (effective August 28, 2026, Genentech, Inc.).
What does the cobimetinib label say about vemurafenib?
Cobimetinib label, warnings and precautionsWARNINGS AND PRECAUTIONS Review the Full Prescribing Information for vemurafenib for information on the serious risks of vemurafenib.
Source: FDA drug label (Cotellic), Genentech, Inc., effective July 29, 2026 (SPL set c387579e-cee0-4334-bd1e-73f93ac1bde6), via openFDA; the full label on DailyMed
What does the vemurafenib label say about cobimetinib?
Vemurafenib's label (effective August 28, 2026) does not name cobimetinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZELBORAF), NDA202429 (Hoffmann La Roche), as published by Genentech, Inc., effective August 28, 2026 (SPL set 38eea320-7e0c-485a-bc30-98c3c45e2763), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobimetinib | Vemurafenib | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once