What the FDA labels say about taking them together
Cobimetinib and efavirenz
Cobimetinib's FDA label of July 29, 2026 names efavirenz in its drug interactions section; the efavirenz label PlainMeds reads does not name cobimetinib. The cobimetinib label: “Avoid concurrent use of COTELLIC and strong or moderate CYP3A inducers including but not limited to carbamazepine, efavirenz, phenytoin, rifampin, and St. John's Wort.”
Check it at the source: the cobimetinib FDA label on DailyMed (effective July 29, 2026, Genentech, Inc.); the efavirenz FDA label on DailyMed (effective March 31, 2024, Cipla USA Inc.).
What does the cobimetinib label say about efavirenz?
Cobimetinib label, drug interactionsAvoid concurrent use of COTELLIC and strong or moderate CYP3A inducers including but not limited to carbamazepine, efavirenz, phenytoin, rifampin, and St. John's Wort [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Cotellic), Genentech, Inc., effective July 29, 2026 (SPL set c387579e-cee0-4334-bd1e-73f93ac1bde6), via openFDA; the full label on DailyMed
What does the efavirenz label say about cobimetinib?
Efavirenz's label (effective March 31, 2024) does not name cobimetinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Efavirenz), Cipla USA Inc., effective March 31, 2024 (SPL set 92603fa5-7a2c-4bfb-9a70-aadb4fba952c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobimetinib | Efavirenz | |
|---|---|---|
| Labeled for | n/a | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.28 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once