What the FDA labels say about taking them together
Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil and naloxone
Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil's FDA label of February 4, 2025 names naloxone in its drug interactions section; the naloxone labels PlainMeds reads (4) do not name cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil. The cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil label: “Patients should be closely monitored for sedation and cognitive effects.”
Check it at the source: the cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil FDA label on DailyMed (effective February 4, 2025, Gilead Sciences, Inc.); the naloxone FDA label on DailyMed (effective August 17, 2026, Emergent Devices Inc.).
What does the cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil label say about naloxone?
Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil label, drug interactionsConcomitant Drug Class/Drug Name: Narcotic Analgesics: buprenorphine/naloxone; Effect on Concentration ↑=Increase, ↓=Decrease: ↑ buprenorphine ↑ norbuprenorphine ↓ naloxone; Clinical Comment: Patients should be closely monitored for sedation and cognitive effects.
Source: FDA drug label (Stribild), Gilead Sciences, Inc., effective February 4, 2025 (SPL set 74ae2a93-b267-444c-8f0f-a2a6522260ee), via openFDA; the full label on DailyMed
What does the naloxone label say about cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil?
Naloxone's label (effective August 17, 2026) and its 3 other brand-application labels do not name cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (NARCAN), Emergent Devices Inc., effective August 17, 2026 (SPL set a0ebc83d-2892-40de-bc0a-775ce90b30db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil | Naloxone | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $150.14 per tablet Stribild tablet | $12.74 per mL 2 mg/2 mL syringe |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once