What the FDA labels say about taking them together
Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil and ethosuximide
Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil's FDA label of February 4, 2025 names ethosuximide in its drug interactions section; the ethosuximide labels PlainMeds reads (2) do not name cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil. The cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil label: “Clinical monitoring is recommended upon coadministration of clonazepam or ethosuximide with STRIBILD.”
Check it at the source: the cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil FDA label on DailyMed (effective February 4, 2025, Gilead Sciences, Inc.); the ethosuximide FDA label on DailyMed (effective June 11, 2026, Chartwell Governmental & Specialty RX, LLC.).
What does the cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil label say about ethosuximide?
Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil label, drug interactionsConcomitant Drug Class/Drug Name: clonazepam ethosuximide; Effect on Concentration ↑=Increase, ↓=Decrease: ↑ clonazepam ↑ ethosuximide; Clinical Comment: Clinical monitoring is recommended upon coadministration of clonazepam or ethosuximide with STRIBILD.
Source: FDA drug label (Stribild), Gilead Sciences, Inc., effective February 4, 2025 (SPL set 74ae2a93-b267-444c-8f0f-a2a6522260ee), via openFDA; the full label on DailyMed
What does the ethosuximide label say about cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil?
Ethosuximide's label (effective June 11, 2026) and its 1 other brand-application label do not name cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ethosuximide), Chartwell Governmental & Specialty RX, LLC., effective June 11, 2026 (SPL set a825265d-ace9-4463-a16d-f6d5e1e31188), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil | Ethosuximide | |
|---|---|---|
| Labeled for | HIV | Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $150.14 per tablet Stribild tablet | $0.243 per capsule 250 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once