What the FDA labels say about taking them together
Cobicistat/darunavir and fluvastatin
Cobicistat/darunavir's FDA label of February 1, 2026 names fluvastatin in its drug interactions section; the fluvastatin labels PlainMeds reads (2) do not name cobicistat/darunavir. The cobicistat/darunavir label: “For atorvastatin, fluvastatin, pitavastatin, pravastatin, and rosuvastatin, start with the lowest recommended dose and titrate while monitoring for safety (e.g. myopathy). …”
Check it at the source: the cobicistat/darunavir FDA label on DailyMed (effective February 1, 2026, Janssen Products, LP); the fluvastatin FDA label on DailyMed (effective April 21, 2025, Teva Pharmaceuticals USA, Inc.).
What does the cobicistat/darunavir label say about fluvastatin?
Cobicistat/darunavir label, drug interactionsConcomitant Drug Class/Drug Name Examples: atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin; Effect on Concentration of Darunavir, Cobicistat, or Concomitant Drug: ↑ atorvastatin ↑ fluvastatin ↑ pravastatin ↑ rosuvastatin pitavastatin: effect unknown; Clinical Comment: For atorvastatin, fluvastatin, pitavastatin, pravastatin, and rosuvastatin, start with the lowest recommended dose and titrate while monitoring for safety (e.g. myopathy). Dosage recommendations with atorvastatin or rosuvastatin are as follows: atorvastatin dosage should not exceed 20 mg/day rosuvastatin dosage should not exceed 20 mg/day
Source: FDA drug label (PREZCOBIX), Janssen Products, LP, effective February 1, 2026 (SPL set 9c38fdb6-d0ba-4f16-a0e3-85d9ec334d9f), via openFDA; the full label on DailyMed
What does the fluvastatin label say about cobicistat/darunavir?
Fluvastatin's label (effective April 21, 2025) and its 1 other brand-application label do not name cobicistat/darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fluvastatin), Teva Pharmaceuticals USA, Inc., effective April 21, 2025 (SPL set aad8b373-0aec-4efb-8e61-3d8114b31127), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat/darunavir | Fluvastatin | |
|---|---|---|
| Labeled for | HIV | High cholesterol |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $79.99 per tablet 800 mg-150 mg tablet | $2.88 per tablet 80 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once