What the FDA labels say about taking them together
Clozapine and propafenone
Clozapine's FDA label of June 6, 2025 names propafenone in its drug interactions section; the propafenone label PlainMeds reads does not name clozapine.
Check it at the source: the clozapine FDA label on DailyMed (effective June 6, 2025, HLS Therapeutics (USA), Inc.); the propafenone FDA label on DailyMed (effective September 1, 2025, Strides Pharma Science Limited).
What does the clozapine label say about propafenone?
Clozapine label, drug interactionsSuch drugs include specific antidepressants, phenothiazines, carbamazepine, and Type 1C antiarrhythmics (e.g., propafenone, flecainide, and encainide).
Source: FDA drug label (Clozaril), NDA019758 (Heritage Life), as published by HLS Therapeutics (USA), Inc., effective June 6, 2025 (SPL set 90876802-0e3a-44c9-9ff7-1754dfbe736a), via openFDA; the full label on DailyMed
What does the propafenone label say about clozapine?
Propafenone's label (effective September 1, 2025) does not name clozapine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PROPAFENONE HYDROCHLORIDE), Strides Pharma Science Limited, effective September 1, 2025 (SPL set c65253ab-937f-4982-b841-69c2b9f9ccdb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clozapine | Propafenone | |
|---|---|---|
| Labeled for | Schizophrenia | Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.610 per tablet 100 mg tablet | $0.115 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once