What the FDA labels say about taking them together
Clorazepate and diazepam
Clorazepate's FDA label of September 10, 2026 names diazepam in its drug interactions section; diazepam's label does not name clorazepate itself but warns about its class (Benzodiazepines). The clorazepate label: “Although early studies reported an increased risk of congenital malformations with diazepam and chlordiazepoxide, there was no consistent pattern noted.”
Check it at the source: the clorazepate FDA label on DailyMed (effective September 10, 2026, Apotex Corp.); the diazepam FDA label on DailyMed (effective August 11, 2026, Waylis Therapuetics LLC).
What does the clorazepate label say about diazepam?
Clorazepate label, drug interactionsAlthough early studies reported an increased risk of congenital malformations with diazepam and chlordiazepoxide, there was no consistent pattern noted.
Source: FDA drug label (Clorazepate Dipotassium), ANDA215566 (Corepharma), as published by Apotex Corp., effective September 10, 2026 (SPL set 6e07efe5-29b6-6d1e-661a-f696c4b17f43), via openFDA; the full label on DailyMed
What does the diazepam label say about clorazepate?
Diazepam's label does not name clorazepate itself; it warns about its class (Benzodiazepines):
Diazepam label, boxed warningABUSE, MISUSE, AND ADDICTION; and DEPENDENCE AND WITHDRAWAL REACTIONS See full prescribing information for complete boxed warning Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. ( 5.1 , 7.1 ) The use of benzodiazepines, including VALTOCO, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death.
Diazepam label, boxed warningABUSE, MISUSE, AND ADDICTION; and DEPENDENCE AND WITHDRAWAL REACTIONS Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.
Source: FDA drug label (Valium), Waylis Therapuetics LLC, effective August 11, 2026 (SPL set 260e2041-2bb3-482f-850e-b5d47a7bdbe6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clorazepate | Diazepam | |
|---|---|---|
| Labeled for | Anxiety, Seizures and epilepsy | Anxiety, Muscle spasms and spasticity |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.524 per tablet 3.75 mg tablet | $0.0283 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once