What the FDA labels say about taking them together
Clopidogrel and resmetirom
Resmetirom's FDA label of July 29, 2026 names clopidogrel in its drug interactions section; the clopidogrel label PlainMeds reads does not name resmetirom. The resmetirom label: “Intervention; Concomitant use of REZDIFFRA with strong CYP2C8 inhibitors (e.g., gemfibrozil) is not recommended. Reduce REZDIFFRA dosage if used concomitantly with a moderate CYP2C8 inhibitor (e.g., clopidogrel) [ see ].”
Check it at the source: the clopidogrel FDA label on DailyMed (effective May 30, 2025, Sanofi-Aventis U.S. LLC); the resmetirom FDA label on DailyMed (effective July 29, 2026, Madrigal Pharmaceuticals, Inc.).
What does the clopidogrel label say about resmetirom?
Clopidogrel's label (effective May 30, 2025) does not name resmetirom in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Plavix), Sanofi-Aventis U.S. LLC, effective May 30, 2025 (SPL set de8b0b67-eb25-4684-83b5-7ad785314227), via openFDA; the full label on DailyMed
What does the resmetirom label say about clopidogrel?
Resmetirom label, drug interactionsIntervention; Concomitant use of REZDIFFRA with strong CYP2C8 inhibitors (e.g., gemfibrozil) is not recommended. Reduce REZDIFFRA dosage if used concomitantly with a moderate CYP2C8 inhibitor (e.g., clopidogrel) [ see ].
Source: FDA drug label (REZDIFFRA), Madrigal Pharmaceuticals, Inc., effective July 29, 2026 (SPL set e67ea09f-a840-439c-86c8-f98585f978b2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clopidogrel | Resmetirom | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Angina | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0472 per tablet 75 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once