What the FDA labels say about taking them together
Clonidine and milnacipran
Milnacipran's FDA label of September 10, 2025 names clonidine in its drug interactions section; the clonidine labels PlainMeds reads (4) do not name milnacipran.
Check it at the source: the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.); the milnacipran FDA label on DailyMed (effective September 10, 2025, Allergan, Inc.).
What does the clonidine label say about milnacipran?
Clonidine's label (effective March 30, 2026) and its 3 other brand-application labels do not name milnacipran in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
What does the milnacipran label say about clonidine?
Milnacipran label, drug interactionsBecause SAVELLA inhibits norepinephrine reuptake, co-administration with clonidine may inhibit clonidine’s anti-hypertensive effect.
Source: FDA drug label (Savella), NDA022256 (Abbvie), as published by Allergan, Inc., effective September 10, 2025 (SPL set 16a4a314-f97e-4e91-95e9-576a3773d284), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonidine | Milnacipran | |
|---|---|---|
| Labeled for | High blood pressure, ADHD, Pain | Nerve pain and fibromyalgia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0241 per tablet 0.1 mg tablet | $2.82 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once