What the FDA labels say about taking them together
Clonidine and isoproterenol
Clonidine's FDA label (Javadin) of October 24, 2025 names isoproterenol in its warnings and precautions section; the isoproterenol label PlainMeds reads does not name clonidine.
Check it at the source: the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.); the isoproterenol FDA label on DailyMed (effective December 16, 2025, Eugia US LLC).
What does the clonidine label say about isoproterenol?
Javadin label (Azurity Pharmaceuticals, Inc., October 24, 2025), warnings and precautionsThere have been post-marketing reports of patients with conduction abnormalities and/or taking other sympatholytic drugs who developed severe bradycardia requiring intravenous (IV) atropine, IV isoproterenol, and temporary cardiac pacing while taking clonidine.
Source: FDA drug label (Javadin, NDA220256), Azurity Pharmaceuticals, Inc., effective October 24, 2025 (SPL set c36d94f5-a30d-4997-b141-e79a4ea45ecf), via openFDA
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
What does the isoproterenol label say about clonidine?
Isoproterenol's label (effective December 16, 2025) does not name clonidine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Isoproterenol Hydrochloride), Eugia US LLC, effective December 16, 2025 (SPL set 3e4050e8-7d94-4ed7-951d-1ff818ddadf1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonidine | Isoproterenol | |
|---|---|---|
| Labeled for | High blood pressure, ADHD, Pain | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0241 per tablet 0.1 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once