What the FDA labels say about taking them together
Clonidine and ephedrine
Ephedrine's FDA label of September 16, 2024 names clonidine in its drug interactions section; the clonidine labels PlainMeds reads (4) do not name ephedrine.
Check it at the source: the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.); the ephedrine FDA label on DailyMed (effective September 16, 2024, Nexus Pharmaceuticals, LLC).
What does the clonidine label say about ephedrine?
Clonidine's label (effective March 30, 2026) and its 3 other brand-application labels do not name ephedrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
What does the ephedrine label say about clonidine?
Ephedrine label, drug interactionsClonidine, propofol, monoamine oxidase inhibitors (MAOIs), atropine Clinical Impact: These drugs augment the pressor effect of ephedrine. Intervention: Carefully monitor the blood pressure of individuals who have received both EMERPHED and EMERPHED-PFS and any of these drugs.
Ephedrine Sulfate label (Par Health USA, LLC, March 17, 2026), drug interactionsClonidine, propofol, monoamine oxidase inhibitors (MAOIs), atropine C linical Impact: These drugs augment the pressor effect of ephedrine.
Source: FDA drug label (Akovaz, NDA208289), Exela Pharma Sciences, LLC, effective November 27, 2020 (SPL set e92f3eda-33eb-4b34-9e8b-db8d32a5dbd9), via openFDA
Source: FDA drug label (Ephedrine Sulfate, NDA208943), Par Health USA, LLC, effective March 17, 2026 (SPL set 38723cb3-dfca-4c81-8c6f-63dd99929191), via openFDA
Source: FDA drug label (Emerphed PFS), Nexus Pharmaceuticals, LLC, effective September 16, 2024 (SPL set 14601778-93ac-43ec-b66b-5a942317133f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonidine | Ephedrine | |
|---|---|---|
| Labeled for | High blood pressure, ADHD, Pain | Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0241 per tablet 0.1 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once