What the FDA labels say about taking them together
Clofarabine and cyclophosphamide
Clofarabine's FDA label of December 12, 2022 names cyclophosphamide in its warnings and precautions section; the cyclophosphamide labels PlainMeds reads (4) do not name clofarabine. The clofarabine label: “… clofarabine (40 mg/m 2 ) when used in combination with etoposide (100 mg/m 2 ) and cyclophosphamide (440 mg/m 2 ).”
Check it at the source: the clofarabine FDA label on DailyMed (effective December 12, 2022, Meitheal Pharmaceuticals Inc.); the cyclophosphamide FDA label on DailyMed (effective January 19, 2026, Amneal Pharmaceuticals LLC).
What does the clofarabine label say about cyclophosphamide?
Clofarabine label, warnings and precautionsDisease of the Liver Patients who have previously received a hematopoietic stem cell transplant (HSCT) are at higher risk for veno-occlusive disease (VOD) of the liver following treatment with clofarabine (40 mg/m 2 ) when used in combination with etoposide (100 mg/m 2 ) and cyclophosphamide (440 mg/m 2 ).
Source: FDA drug label (Clofarabine), Meitheal Pharmaceuticals Inc., effective December 12, 2022 (SPL set 54436453-882e-406b-87a3-049d150101c6), via openFDA; the full label on DailyMed
What does the cyclophosphamide label say about clofarabine?
Cyclophosphamide's label (effective January 19, 2026) and its 3 other brand-application labels do not name clofarabine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cyclophosphamide), Amneal Pharmaceuticals LLC, effective January 19, 2026 (SPL set 520bfe39-dfd5-4a20-9a37-80078afded0d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clofarabine | Cyclophosphamide | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Leukemia, lymphoma and myeloma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.67 per capsule 50 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once