What the FDA labels say about taking them together

Clobazam and stiripentol

Stiripentol's FDA label of April 27, 2026 names clobazam in its drug interactions section; the clobazam labels PlainMeds reads (2) do not name stiripentol. The stiripentol label: “DRUG INTERACTIONS DIACOMIT increases the plasma concentration of clobazam and its metabolite through metabolic inhibition of CYP3A4 and CYP2C19.”

Check it at the source: the clobazam FDA label on DailyMed (effective March 12, 2024, Lundbeck Pharmaceuticals LLC); the stiripentol FDA label on DailyMed (effective April 27, 2026, BIOCODEX, INC.).

What does the clobazam label say about stiripentol?

Clobazam's label (effective March 12, 2024) and its 1 other brand-application label do not name stiripentol in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Onfi), Lundbeck Pharmaceuticals LLC, effective March 12, 2024 (SPL set de03bd69-2dca-459c-93b4-541fd3e9571c), via openFDA; the full label on DailyMed

What does the stiripentol label say about clobazam?

Stiripentol label, drug interactions
DRUG INTERACTIONS DIACOMIT increases the plasma concentration of clobazam and its metabolite through metabolic inhibition of CYP3A4 and CYP2C19.

Stiripentol label, warnings and precautions
If somnolence occurs during co-administration with clobazam, consider an initial reduction of clobazam by 25%. ( 5.1 ) Decreased Appetite and Decreased Weight: the weight of patients and the growth rate of pediatric patients should be carefully monitored. ( 5.2 ) Neutropenia and Thrombocytopenia:

Source: FDA drug label (Diacomit), BIOCODEX, INC., effective April 27, 2026 (SPL set 58304ba8-9779-4658-811e-94ffe08c3f16), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

16Clobazam generic labelers

0Stiripentol generic labelers

	Clobazam	Stiripentol
Labeled for	n/a	n/a
Boxed warning	Yes	No
Pharmacy cost (NADAC)	$0.243 per tablet 10 mg tablet	n/a
Shortage now	No current entry	No current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?

Clobazam: the full record
Stiripentol: the full record
Check more medicines together: up to five at once