What the FDA labels say about taking them together
Clobazam and eslicarbazepine
Eslicarbazepine's FDA label of November 10, 2023 names clobazam in its drug interactions section; the clobazam labels PlainMeds reads (2) do not name eslicarbazepine. The eslicarbazepine label: “CYP2C19 Substrates APTIOM can inhibit CYP2C19, which can cause increased plasma concentrations of drugs that are metabolized by this isoenzyme.”
Check it at the source: the clobazam FDA label on DailyMed (effective March 12, 2024, Lundbeck Pharmaceuticals LLC); the eslicarbazepine FDA label on DailyMed (effective November 10, 2023, Sumitomo Pharma America, Inc.).
What does the clobazam label say about eslicarbazepine?
Clobazam's label (effective March 12, 2024) and its 1 other brand-application label do not name eslicarbazepine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Onfi), Lundbeck Pharmaceuticals LLC, effective March 12, 2024 (SPL set de03bd69-2dca-459c-93b4-541fd3e9571c), via openFDA; the full label on DailyMed
What does the eslicarbazepine label say about clobazam?
Eslicarbazepine label, drug interactionsCYP2C19 Substrates APTIOM can inhibit CYP2C19, which can cause increased plasma concentrations of drugs that are metabolized by this isoenzyme (e.g., phenytoin, clobazam, and omeprazole) [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Aptiom), Sumitomo Pharma America, Inc., effective November 10, 2023 (SPL set 3d0c9554-eaeb-4694-8089-00133fcadce3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clobazam | Eslicarbazepine | |
|---|---|---|
| Labeled for | n/a | Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.243 per tablet 10 mg tablet | $1.68 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once