What the FDA labels say about taking them together
Clarithromycin and voclosporin
Voclosporin's FDA label of August 25, 2026 names clarithromycin in its contraindications section; the clarithromycin label PlainMeds reads does not name voclosporin. The voclosporin label: “Co-administration of LUPKYNIS with strong CYP3A4 inhibitors is contraindicated.”
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the voclosporin FDA label on DailyMed (effective August 25, 2026, Aurinia Pharma U.S., Inc.).
What does the clarithromycin label say about voclosporin?
Clarithromycin's label (effective April 9, 2026) does not name voclosporin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the voclosporin label say about clarithromycin?
Voclosporin label, contraindicationsCONTRAINDICATIONS LUPKYNIS is contraindicated in: Patients concomitantly using strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin) because these medications can significantly increase exposure to LUPKYNIS which may increase the risk of acute and/or chronic nephrotoxicity [see Warnings and Precautions ( 5.3 ), Drug Interactions ( 7.1 ), and Pharmacokinetics ( 12.3 )].
Voclosporin label, drug interactionsCo-administration of LUPKYNIS with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin) is contraindicated [see Contraindications ( 4 )].
Source: FDA drug label (LUPKYNIS), Aurinia Pharma U.S., Inc., effective August 25, 2026 (SPL set 9f489295-1156-52c7-5fd0-5c4c52f9b813), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Voclosporin | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once