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What the FDA labels say about taking them together

Clarithromycin and vandetanib

Vandetanib's FDA label of April 23, 2026 names clarithromycin in its warnings and precautions section; the clarithromycin label PlainMeds reads does not name vandetanib. The vandetanib label: “Avoid administration of CAPRELSA with anti-arrhythmic drugs and other drugs that may prolong the QT interval.”

Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the vandetanib FDA label on DailyMed (effective April 23, 2026, Genzyme Corporation).

What does the clarithromycin label say about vandetanib?

Clarithromycin's label (effective April 9, 2026) does not name vandetanib in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed

What does the vandetanib label say about clarithromycin?

Vandetanib label, warnings and precautions

Avoid administration of CAPRELSA with anti-arrhythmic drugs (including but not limited to amiodarone, disopyramide, procainamide, sotalol, dofetilide) and other drugs that may prolong the QT interval (including but not limited to chloroquine, clarithromycin, dolasetron, granisetron, haloperidol, methadone, moxifloxacin, and pimozide) [see Drug Interactions (7.4) and Clinical Pharmacology (12.2) ].

Source: FDA drug label (CAPRELSA), Genzyme Corporation, effective April 23, 2026 (SPL set e5721cb8-4185-47b9-bbb3-1c587e558a03), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

26Clarithromycin generic labelers
0Vandetanib generic labelers
ClarithromycinVandetanib
Labeled forBacterial infections, Acid reflux and ulcersn/a
Boxed warningNoYes
Pharmacy cost (NADAC)$0.466 per tablet 500 mg tabletn/a
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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