What the FDA labels say about taking them together
Clarithromycin and tolterodine
Clarithromycin's FDA label of April 9, 2026 names tolterodine in its drug interactions section, and tolterodine's label names clarithromycin too. The tolterodine label: “For patients receiving ketoconazole or other potent CYP3A4 inhibitors such as other azole antifungals or macrolide antibiotics or cyclosporine or vinblastine, the recommended dose of DETROL is 1 mg twice daily.”
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the tolterodine FDA label on DailyMed (effective February 9, 2026, Torrent Pharmaceuticals Limited).
What does the clarithromycin label say about tolterodine?
Clarithromycin label, drug interactionsLurasidone Lurasidone: [See Contraindications (4.7) ] Antispasmodics: Tolterodine (patients deficient in CYP2D6 activity) Use With Caution Tolterodine:
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the tolterodine label say about clarithromycin?
Tolterodine label, drug interactionsFor patients receiving ketoconazole or other potent CYP3A4 inhibitors such as itraconazole, clarithromycin, or ritonavir, the recommended dose of tolterodine tartrate extended-release capsules is 2 mg once daily [ see DOSAGE AND ADMINISTRATION ( 2.2) and CLINICAL PHARMACOLOGY ( 12.3) ].
Detrol label (Viatris Specialty LLC, February 15, 2023), drug interactionsFor patients receiving ketoconazole or other potent CYP3A4 inhibitors such as other azole antifungals (e.g., itraconazole, miconazole) or macrolide antibiotics (e.g., erythromycin, clarithromycin) or cyclosporine or vinblastine, the recommended dose of DETROL is 1 mg twice daily (see DOSAGE AND ADMINISTRATION ).
Source: FDA drug label (Detrol, NDA020771), Viatris Specialty LLC, effective February 15, 2023 (SPL set 41eb00d2-64e3-4ec9-8732-4bfc81b04180), via openFDA
Source: FDA drug label (TOLTERODINE TARTRATE), Torrent Pharmaceuticals Limited, effective February 9, 2026 (SPL set db6e0b6d-0ce5-41d7-881f-881c11f530a4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Tolterodine | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Overactive bladder |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | $0.268 per capsule 2 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once