What the FDA labels say about taking them together
Clarithromycin and tadalafil
Clarithromycin's FDA label of April 9, 2026 names tadalafil in its drug interactions section; the tadalafil labels PlainMeds reads (3) do not name clarithromycin.
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the tadalafil FDA label on DailyMed (effective June 3, 2026, Eli Lilly and Company).
What does the clarithromycin label say about tadalafil?
Clarithromycin label, drug interactionsPhosphodiesterase inhibitors: Sildenafil Tadalafil Vardenafil Use With Caution Sildenafil, Tadalafil, Vardenafil:
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the tadalafil label say about clarithromycin?
Tadalafil's label (effective June 3, 2026) and its 2 other brand-application labels do not name clarithromycin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cialis), Eli Lilly and Company, effective June 3, 2026 (SPL set bcd8f8ab-81a2-4891-83db-24a0b0e25895), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Tadalafil | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Erectile dysfunction, Enlarged prostate (BPH), Pulmonary arterial hypertension |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | $0.167 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once