Clarithromycin and Sotalol Interaction
Drug interaction information between Clarithromycin and Sotalol.
Clarithromycin and Sotalol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clarithromycin and Sotalol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin interferes with how this heart medication is handled by the body, potentially leading to serious heart rhythm issues.
FDA Label Information
Clinically Significant Drug Interactions with Clarithromycin Tablets Drugs That Are Affected By Clarithromycin Tablets Drug(s) with Pharmacokinetics Affected by Clarithromycin Tablets Recommendation Comments Antiarrhythmics: Disopyramide Quinidine Dofetilide Amiodarone Sotalol Procainamide Not Recommended Disopyramide, Quinidine: There have been postmarketing reports of torsades de pointes occurring with concurrent use of clarithromycin and quinidine or disopyramide.
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Sotalol Also Interacts With
- Clonidine moderate
- Amiodarone moderate
- Digoxin moderate
- Albuterol minor
- Diltiazem minor
Frequently Asked Questions
What SPL severity band is on file for Clarithromycin + Sotalol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Sotalol's 13. In the moderate band specifically: Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Sildenafil, Valproate); Sotalol has 4 (also Clonidine, Amiodarone, Digoxin).
What mechanism field is on file for Clarithromycin and Sotalol?
Clarithromycin interferes with how this heart medication is handled by the body, potentially leading to serious heart rhythm issues.
Clarithromycin carries more major-labeled pairs than Sotalol
SPL source-record counts only. This page's band is moderate · classes on file: Clarithromycin (Macrolide Antibiotic); Sotalol (Class III Antiarrhythmic / Beta-Blocker).
Clarithromycin has 16 major-labeled pairs vs Sotalol's 0. This page itself is in the moderate band, not the major band.
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Sildenafil
- Valproate
0 major · 4 moderate · 9 minor · 13 total
- Other moderate peers for Sotalol
- Clonidine
- Amiodarone
- Digoxin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.