What the FDA labels say about taking them together
Clarithromycin and silodosin
Silodosin's FDA label of April 15, 2026 names clarithromycin in its contraindications section; the clarithromycin label PlainMeds reads does not name silodosin. The silodosin label: “Concomitant use of ketoconazole or other strong CYP3A4 inhibitors is therefore contraindicated.”
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the silodosin FDA label on DailyMed (effective April 15, 2026, Amneal Pharmaceuticals NY LLC).
What does the clarithromycin label say about silodosin?
Clarithromycin's label (effective April 9, 2026) does not name silodosin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the silodosin label say about clarithromycin?
Silodosin label, contraindicationsCONTRAINDICATIONS Severe renal impairment (CCr < 30 mL/min) Severe hepatic impairment (Child-Pugh score ≥ 10) Concomitant administration with strong Cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ketoconazole, clarithromycin, itraconazole, ritonavir) [see Drug Interactions (7.1) ] Patients with a history of hypersensitivity to silodosin or any of the ingredients of silodosin capsules [see Adverse Reactions (6.2) and Description (11) ] Patients with severe renal impairment [Creatinine Clearance (CCr < 30 mL/min)]. ( 4 ) Patients with severe hepatic impairment (Child-Pugh score > 10). …
Silodosin label, warnings and precautionsConcomitant use of ketoconazole or other strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin, ritonavir) is therefore contraindicated [see Drug Interactions (7.1) ].
Source: FDA drug label (Silodosin), Amneal Pharmaceuticals NY LLC, effective April 15, 2026 (SPL set de619e27-9384-4b86-abdc-de0557cd39e8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Silodosin | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Enlarged prostate (BPH) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | $0.319 per capsule 8 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once