What the FDA labels say about taking them together
Clarithromycin and osilodrostat
Osilodrostat's FDA label of November 18, 2025 names clarithromycin in its drug interactions section; the clarithromycin label PlainMeds reads does not name osilodrostat. The osilodrostat label: “Concomitant use of ISTURISA with a strong CYP3A4 inhibitor may cause an increase in osilodrostat concentration and may increase the risk of ISTURISA-related adverse reactions.”
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the osilodrostat FDA label on DailyMed (effective November 18, 2025, Recordati Rare Diseases, Inc.).
What does the clarithromycin label say about osilodrostat?
Clarithromycin's label (effective April 9, 2026) does not name osilodrostat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the osilodrostat label say about clarithromycin?
Osilodrostat label, drug interactionsCYP3A4 Inhibitors Clinical Impact: Concomitant use of ISTURISA with a strong CYP3A4 inhibitor (…) may cause an increase in osilodrostat concentration and may increase the risk of ISTURISA-related adverse reactions. Intervention: Reduce the dose of ISTURISA by half with concomitant use of a strong CYP3A4 inhibitor.
Source: FDA drug label (Isturisa), Recordati Rare Diseases, Inc., effective November 18, 2025 (SPL set f3a5ec24-63c3-4d83-b1c0-6c550fbe7ae2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Osilodrostat | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once