What the FDA labels say about taking them together
Clarithromycin and naloxegol
Naloxegol's FDA label of September 1, 2026 names clarithromycin in its contraindications section; the clarithromycin label PlainMeds reads does not name naloxegol. The naloxegol label: “•Use with strong CYP3A4 inhibitors is contraindicated.”
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the naloxegol FDA label on DailyMed (effective September 1, 2026, Averitas Pharma, Inc.).
What does the clarithromycin label say about naloxegol?
Clarithromycin's label (effective April 9, 2026) does not name naloxegol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the naloxegol label say about clarithromycin?
Naloxegol label, contraindicationsPatients concomitantly using strong CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole) because these medications can significantly increase exposure to naloxegol which may precipitate opioid withdrawal symptoms such as hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning [see Drug Interactions (7.1) and Clinical Pharmacology (12.3) ].
Naloxegol label, drug interactionsConcomitant Agent: •Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin); Mechanism of Action: •Increase plasma naloxegol concentrations and may increase the risk of adverse reactions [see ].; Clinical Recommendation: •Use with strong CYP3A4 inhibitors is contraindicated [see ].
Source: FDA drug label (MOVANTIK), Averitas Pharma, Inc., effective September 1, 2026 (SPL set 28596788-b73f-4247-85fc-3105f51fff5a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Naloxegol | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | $14.61 per tablet 25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once