What the FDA labels say about taking them together
Clarithromycin and fluvastatin
Clarithromycin's FDA label of April 9, 2026 names fluvastatin in its drug interactions section; the fluvastatin labels PlainMeds reads (2) do not name clarithromycin. The clarithromycin label: “… increasing the risk of toxicities from these drugs Atorvastatin, Pravastatin, Fluvastatin:”
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the fluvastatin FDA label on DailyMed (effective April 21, 2025, Teva Pharmaceuticals USA, Inc.).
What does the clarithromycin label say about fluvastatin?
Clarithromycin label, drug interactionsLomitapide Lovastatin Simvastatin; Contraindicated; Lomitapide, Lovastatin, Simvastatin: Clarithromycin may increase the exposure of these drugs by inhibition of CYP3A metabolism, thereby increasing the risk of toxicities from these drugs [See Contraindications and Warnings and Precautions ] Atorvastatin, Pravastatin, Fluvastatin: [See Warnings and Precautions ]
Clarithromycin label, warnings and precautionsUse of a statin that is not dependent on CYP3A metabolism (e.g., fluvastatin) can be considered.
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the fluvastatin label say about clarithromycin?
Fluvastatin's label (effective April 21, 2025) and its 1 other brand-application label do not name clarithromycin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fluvastatin), Teva Pharmaceuticals USA, Inc., effective April 21, 2025 (SPL set aad8b373-0aec-4efb-8e61-3d8114b31127), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Fluvastatin | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | High cholesterol |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | $2.88 per tablet 80 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once