Clarithromycin · more major-labeled pairs than Apixaban
SPL labels Clarithromycin + Apixaban as minor; Clarithromycin 30 / Apixaban 3 in that band.
Mechanism on file: Clarithromycin blocks the enzymes that break down apixaban, but the effect is not strong enough to require a change.
FDA SPL severity: Minor
Clarithromycin + Apixaban · SPL mechanism field
Clarithromycin blocks the enzymes that break down apixaban, but the effect is not strong enough to require a change.
Minor band excerpt · Clarithromycin with Apixaban
Clarithromycin Although clarithromycin is a combined P-gp and strong CYP3A4 inhibitor, pharmacokinetic data suggest that no dose adjustment is necessary with concomitant administration with apixaban [see Clinical Pharmacology ( 12.3) ].
Clarithromycin · 16 major-labeled pairs (vs Apixaban's 0)
- Amlodipine minor
- Aripiprazole minor
- Carbamazepine minor
- Dabigatran minor
Apixaban · 3 minor + 12 total pairs
- Itraconazole minor
- Ketoconazole minor
- Aspirin moderate
- Carbamazepine moderate
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.