What the FDA labels say about taking them together
Cladribine and cyclosporine
Cladribine's FDA label of May 27, 2026 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name cladribine. The cladribine label: “Prevention or Management; Avoid co-administration of potent ENT1, CNT3, or BCRP transporter inhibitors during the 4 to 5 day MAVENCLAD treatment cycles. …”
Check it at the source: the cladribine FDA label on DailyMed (effective May 27, 2026, EMD Serono, Inc.); the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation).
What does the cladribine label say about cyclosporine?
Cladribine label, drug interactionsPrevention or Management; Avoid co-administration of potent ENT1, CNT3, or BCRP transporter inhibitors (e.g., ritonavir, eltrombopag, curcumin, cyclosporine, dilazep, nifedipine, nimodipine, cilostazol, sulindac, dipyridamole, or reserpine) during the 4 to 5 day MAVENCLAD treatment cycles. If this is not possible, consider selection of alternative concomitant drugs with no or minimal ENT1, CNT3, or BCRP transporter inhibiting properties. If this is not possible, dose reduction to the minimum mandatory dose of drugs containing these compounds, separation in the timing of administration, and careful patient monitoring is recommended.
Source: FDA drug label (Mavenclad), EMD Serono, Inc., effective May 27, 2026 (SPL set 9c75e30a-a410-40f1-b653-04d532bd9144), via openFDA; the full label on DailyMed
What does the cyclosporine label say about cladribine?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name cladribine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cladribine | Cyclosporine | |
|---|---|---|
| Labeled for | Multiple sclerosis, Leukemia, lymphoma and myeloma | Organ transplant rejection, Rheumatoid arthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $1.04 per unit 0.05% eye emulsion |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once