What the FDA labels say about taking them together
Cisplatin and trilaciclib
Trilaciclib's FDA label of August 31, 2025 names cisplatin in its drug interactions section; the cisplatin label PlainMeds reads does not name trilaciclib. The trilaciclib label: “Closely monitor for nephrotoxicity.; Comments: Concurrent treatment with COSELA may increase the exposure and alter the net accumulation of cisplatin in the kidney, which may associate with dose-related nephrotoxicity.”
Check it at the source: the cisplatin FDA label on DailyMed (effective September 16, 2021, WG Critical Care, LLC); the trilaciclib FDA label on DailyMed (effective August 31, 2025, Pharmacosmos Therapeutics Inc.).
What does the cisplatin label say about trilaciclib?
Cisplatin's label (effective September 16, 2021) does not name trilaciclib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (CISplatin), NDA018057 (Hq Spclt Pharma), as published by WG Critical Care, LLC, effective September 16, 2021 (SPL set 2bf8d2fb-80c8-401d-8e9b-d58463f5e954), via openFDA; the full label on DailyMed
What does the trilaciclib label say about cisplatin?
Trilaciclib label, drug interactionsDrugs: Cisplatin; Recommendations: Closely monitor for nephrotoxicity.; Comments: Concurrent treatment with COSELA may increase the exposure and alter the net accumulation of cisplatin in the kidney, which may associate with dose-related nephrotoxicity.
Source: FDA drug label (COSELA), Pharmacosmos Therapeutics Inc., effective August 31, 2025 (SPL set b3179c19-78f3-4bf1-b73e-7f7638522ab1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cisplatin | Trilaciclib | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once