What the FDA labels say about taking them together
Cisplatin and rituximab
Rituximab's FDA label of January 6, 2025 names cisplatin in its drug interactions section; the cisplatin label PlainMeds reads does not name rituximab. The rituximab label: “Renal toxicity when used in combination with cisplatin.”
Check it at the source: the cisplatin FDA label on DailyMed (effective September 16, 2021, WG Critical Care, LLC); the rituximab FDA label on DailyMed (effective January 6, 2025, Genentech, Inc.).
What does the cisplatin label say about rituximab?
Cisplatin's label (effective September 16, 2021) does not name rituximab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (CISplatin), NDA018057 (Hq Spclt Pharma), as published by WG Critical Care, LLC, effective September 16, 2021 (SPL set 2bf8d2fb-80c8-401d-8e9b-d58463f5e954), via openFDA; the full label on DailyMed
What does the rituximab label say about cisplatin?
Rituximab label, drug interactionsRenal toxicity when used in combination with cisplatin ( 5.8 ).
Rituximab label, warnings and precautionsRenal toxicity has occurred in patients who experience tumor lysis syndrome and in patients with NHL administered concomitant cisplatin therapy during clinical trials.
Source: FDA drug label (Rituxan), Genentech, Inc., effective January 6, 2025 (SPL set b172773b-3905-4a1c-ad95-bab4b6126563), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cisplatin | Rituximab | |
|---|---|---|
| Labeled for | n/a | Leukemia, lymphoma and myeloma, Rheumatoid arthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once