What the FDA labels say about taking them together
Cisplatin and melphalan
Melphalan's FDA label of July 7, 2026 names cisplatin in its drug interactions section; the cisplatin label PlainMeds reads does not name melphalan.
Check it at the source: the cisplatin FDA label on DailyMed (effective September 16, 2021, WG Critical Care, LLC); the melphalan FDA label on DailyMed (effective July 7, 2026, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.).
What does the cisplatin label say about melphalan?
Cisplatin's label (effective September 16, 2021) does not name melphalan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (CISplatin), NDA018057 (Hq Spclt Pharma), as published by WG Critical Care, LLC, effective September 16, 2021 (SPL set 2bf8d2fb-80c8-401d-8e9b-d58463f5e954), via openFDA; the full label on DailyMed
What does the melphalan label say about cisplatin?
Melphalan label, drug interactionsCisplatin may affect melphalan kinetics by inducing renal dysfunction and subsequently altering melphalan clearance.
Ivra label (Apotex Corp, September 4, 2025), drug interactionsDRUG INTERACTIONS 7.1 Effect of Other Drugs on IVRA Cisplatin Concomitant use with cisplatin may alter melphalan clearance by inducing renal dysfunction.
Source: FDA drug label (Ivra, NDA217110), Apotex Corp, effective September 4, 2025 (SPL set c23e868a-dc62-2181-5099-76c9226602b2), via openFDA
Source: FDA drug label (Melphalan hydrochloride), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective July 7, 2026 (SPL set 2c18beeb-7bd4-4591-94cb-9d7156c1b8e0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cisplatin | Melphalan | |
|---|---|---|
| Labeled for | n/a | Leukemia, lymphoma and myeloma |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once