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What the FDA labels say about taking them together

Cisatracurium and procainamide

Cisatracurium's FDA label of April 4, 2025 names procainamide in its drug interactions section; the procainamide label PlainMeds reads does not name cisatracurium. The cisatracurium label: “DRUG INTERACTIONS Succinylcholine: May decrease time to onset of maximum neuromuscular blockade. I nhalational anesthetics, antibiotics, local anesthetics, magnesium salts, procainamide, lithium, quinidine:”

Check it at the source: the cisatracurium FDA label on DailyMed (effective April 4, 2025, Gland Pharma Limited); the procainamide FDA label on DailyMed (effective February 17, 2025, Caplin Steriles Limited).

What does the cisatracurium label say about procainamide?

Cisatracurium label, drug interactions

DRUG INTERACTIONS Succinylcholine: May decrease time to onset of maximum neuromuscular blockade. (7.1) I nhalational anesthetics, antibiotics, local anesthetics, magnesium salts, procainamide, lithium, quinidine:

Cisatracurium label, warnings and precautions

Certain drugs may enhance the neuromuscular blocking action of cisatracurium besylate injection including inhalational anesthetics, antibiotics, magnesium salts, lithium, local anesthetics, procainamide and quinidine [ see Drug Interactions (7.1 )].

Source: FDA drug label (Cisatracurium besylate), Gland Pharma Limited, effective April 4, 2025 (SPL set 0bacc37a-5e7f-4f05-9206-56fc8041c1ad), via openFDA; the full label on DailyMed

What does the procainamide label say about cisatracurium?

Procainamide's label (effective February 17, 2025) does not name cisatracurium in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Procainamide Hydrochloride), Caplin Steriles Limited, effective February 17, 2025 (SPL set fcaa5e9a-3c8a-4796-aa87-626268b6cf60), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

15Cisatracurium generic labelers
11Procainamide generic labelers
CisatracuriumProcainamide
Labeled forn/an/a
Boxed warningNoYes
Pharmacy cost (NADAC)n/an/a
Shortage nowA presentation being discontinuedNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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