What the FDA labels say about taking them together
Cinacalcet and metoprolol
Cinacalcet's FDA label of April 2, 2026 names metoprolol in its drug interactions section; the metoprolol labels PlainMeds reads (4) do not name cinacalcet. The cinacalcet label: “Dose adjustments may be required for concomitant medications that are predominantly metabolized by CYP2D6 and particularly those with a narrow therapeutic index.”
Check it at the source: the cinacalcet FDA label on DailyMed (effective April 2, 2026, Aurobindo Pharma Limited); the metoprolol FDA label on DailyMed (effective March 3, 2026, Melinta Therapeutics, LLC).
What does the cinacalcet label say about metoprolol?
Cinacalcet label, drug interactionsDose adjustments may be required for concomitant medications that are predominantly metabolized by CYP2D6 (e.g., desipramine, metoprolol, and carvedilol) and particularly those with a narrow therapeutic index (e.g., flecainide and most tricyclic antidepressants) [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Cinacalcet), Aurobindo Pharma Limited, effective April 2, 2026 (SPL set 200390f2-7dad-4ecc-a086-c29e18525c01), via openFDA; the full label on DailyMed
What does the metoprolol label say about cinacalcet?
Metoprolol's label (effective March 3, 2026) and its 3 other brand-application labels do not name cinacalcet in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TOPROL XL), Melinta Therapeutics, LLC, effective March 3, 2026 (SPL set 496ddfaa-7c9c-4888-b747-a210249b367a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cinacalcet | Metoprolol | |
|---|---|---|
| Labeled for | n/a | High blood pressure, Angina, Heart failure, Heart attack and coronary artery disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.411 per tablet 30 mg tablet | $0.085 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once