What the FDA labels say about taking them together
Cinacalcet and itraconazole
Cinacalcet's FDA label of April 2, 2026 names itraconazole in its drug interactions section, and itraconazole's label names cinacalcet too. The itraconazole label: “Alitretinoin (oral) Cabergoline Cannabinoids Cinacalcet Ivacaftor Monitor for adverse reactions.”
Check it at the source: the cinacalcet FDA label on DailyMed (effective April 2, 2026, Aurobindo Pharma Limited); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the cinacalcet label say about itraconazole?
Cinacalcet label, drug interactionsDose adjustment of cinacalcet may be required if a patient initiates or discontinues therapy with a strong CYP3A4 inhibitor (e.g., ketoconazole, itraconazole).
Source: FDA drug label (Sensipar, NDA021688), Amgen Inc, effective December 7, 2025 (SPL set 45028573-13c4-4c8b-ae62-6c75bba97c81), via openFDA
Source: FDA drug label (Cinacalcet), Aurobindo Pharma Limited, effective April 2, 2026 (SPL set 200390f2-7dad-4ecc-a086-c29e18525c01), via openFDA; the full label on DailyMed
What does the itraconazole label say about cinacalcet?
Itraconazole label, drug interactionsAlitretinoin (oral) Cabergoline Cannabinoids Cinacalcet Galantamine Ivacaftor Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cinacalcet | Itraconazole | |
|---|---|---|
| Labeled for | n/a | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.411 per tablet 30 mg tablet | $0.910 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once