What the FDA labels say about taking them together
Cinacalcet and desipramine
Cinacalcet's FDA label of April 2, 2026 names desipramine in its drug interactions section; the desipramine labels PlainMeds reads (2) do not name cinacalcet. The cinacalcet label: “Dose adjustments may be required for concomitant medications that are predominantly metabolized by CYP2D6 and particularly those with a narrow therapeutic index.”
Check it at the source: the cinacalcet FDA label on DailyMed (effective April 2, 2026, Aurobindo Pharma Limited); the desipramine FDA label on DailyMed (effective July 9, 2025, Alembic Pharmaceuticals Inc.).
What does the cinacalcet label say about desipramine?
Cinacalcet label, drug interactionsDose adjustments may be required for concomitant medications that are predominantly metabolized by CYP2D6 (e.g., desipramine, metoprolol, and carvedilol) and particularly those with a narrow therapeutic index (e.g., flecainide and most tricyclic antidepressants) [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Cinacalcet), Aurobindo Pharma Limited, effective April 2, 2026 (SPL set 200390f2-7dad-4ecc-a086-c29e18525c01), via openFDA; the full label on DailyMed
What does the desipramine label say about cinacalcet?
Desipramine's label (effective July 9, 2025) and its 1 other brand-application label do not name cinacalcet in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (DESIPRAMINE HYDROCHLORIDE), Alembic Pharmaceuticals Inc., effective July 9, 2025 (SPL set cad14805-64d8-4257-b5f1-d56e0063f0e2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cinacalcet | Desipramine | |
|---|---|---|
| Labeled for | n/a | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.411 per tablet 30 mg tablet | $0.276 per tablet 75 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once