What the FDA labels say about taking them together
Cimetidine and trimipramine
Trimipramine's FDA label of March 17, 2026 names cimetidine in its drug interactions section; cimetidine's label does not name trimipramine itself but warns about its class (Tricyclic antidepressants).
Check it at the source: the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.); the trimipramine FDA label on DailyMed (effective March 17, 2026, Breckenridge Pharmaceutical, Inc.).
What does the cimetidine label say about trimipramine?
Cimetidine's label does not name trimipramine itself; it warns about its class (Tricyclic antidepressants):
Cimetidine label, drug interactionsDrug Interactions Cimetidine tablets, apparently through an effect on certain microsomal enzyme systems, has been reported to reduce the hepatic metabolism of warfarin-type anticoagulants, phenytoin, propranolol, nifedipine, chlordiazepoxide, diazepam, certain tricyclic antidepressants, lidocaine, theophylline, and metronidazole, thereby delaying elimination and increasing blood levels of these drugs.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
What does the trimipramine label say about cimetidine?
Trimipramine label, drug interactionsDrug Interactions Cimetidine There is evidence that cimetidine inhibits the elimination of tricyclic antidepressants.
Source: FDA drug label (Trimipramine), Breckenridge Pharmaceutical, Inc., effective March 17, 2026 (SPL set 4f31df66-7dc2-1f04-e054-00144ff88e88), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cimetidine | Trimipramine | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.236 per tablet 300 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once