What the FDA labels say about taking them together
Cimetidine and triazolam
Triazolam's FDA label of July 10, 2026 names cimetidine in its warnings and precautions section; the cimetidine label PlainMeds reads does not name triazolam. The triazolam label: “Cimetidine Coadministration of cimetidine increased the maximum plasma concentration, decreased clearance and increased half-life of triazolam; …”
Check it at the source: the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.); the triazolam FDA label on DailyMed (effective July 10, 2026, Mylan Pharmaceuticals Inc.).
What does the cimetidine label say about triazolam?
Cimetidine's label (effective July 15, 2026) does not name triazolam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
What does the triazolam label say about cimetidine?
Triazolam label, warnings and precautionsCimetidine Coadministration of cimetidine increased the maximum plasma concentration, decreased clearance and increased half-life of triazolam [see Drug Interactions (7.1), Clinical Pharmacology (12.3) ]; caution and consideration of appropriate triazolam dose reduction are recommended.
Source: FDA drug label (Triazolam), NDA017892 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective July 10, 2026 (SPL set 5add318e-11b9-42f8-b052-0d8cebb32fcf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cimetidine | Triazolam | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Insomnia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.236 per tablet 300 mg tablet | $0.308 per tablet 0.25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once